For centuries, scientists have longed to view the molecular components that govern life’s processes. To satisfy this curiosity, powerful imaging tools such as electron microscopes have continued to evolve – capable of revealing exquisite details of biological materials. Using these state-of-the-art instruments, we can better investigate never-before-seen virus pathogens that threaten human health or cause global pandemics. As a complement to cryo-Electron Microscopy (EM) interest in liquid-EM has skyrocketed in the last decade. It has quickly become the premier way to study molecules live in solution as they would perform in the human body. Its main utility is revealing structural dynamics, permitting us to see tiny samples in action. This feature sets liquid-EM apart from other current imaging modalities. Revealing novel information for both structure and function of molecules is a unique benefit of the technique, which continues to gain popularity in both materials and life sciences. By implementing automated tools to improve data collection routines and image processing procedures, the liquid-EM field is primed to assert the “real-time revolution” in atomic analysis, providing a dynamic complement that is missing from other analytical techniques.