Casasanta MA, Jonaid GM, Kaylor L, Luqiu WY, DiCecco L-A, Solares MJ, Berry S, DearnaleyWJ, and Kelly DF* (2022) Structural insights of the SARS-CoV-2 Nucleocapsid protein: implications for the inner-workings of rapid antigen tests. Microscopy & Microanalysis (https://doi.org/10.1093/micmic/ozac036). Cover figure

Solares MJ, and Kelly DF* (2022) Complete models of p53 better inform the impact of hotspot mutations. International J. Mol. Sciences 23 (23) 15267.

DiCecco L-A, Berry S, Jonaid GM, Solares M, Kaylor L, Gray JL, Bator C, Dearnaley WJ, Spilman MS, Dressel-Dukes MJ, Grandfield K, McDonald Esstman SM, Kelly DF* (2022) Advancing High-resolution imaging of viral assemblies in liquid and ice. J. Vis. Exp (185). doi: 10.3791/63856.

Kelly DF*, DiCecco L-A, Jonaid GM, Dearnaley WJ, Spilman MS, Gray JL, Duke MJ (2022) Liquid-EM goes viral – visualizing structure and dynamics. Current Opinion in Structural Biology 75:102426.

Solares MJ and Kelly DF* (2022) Harnessing the Power of Structural Oncology. Microscopy Today (30) 10-17. Cover figure

Solares MJ, Jonaid GM, Luqiu WY, Berry S, Khadela J, Evans MC, Pridham KJ, Dearnaley WJ, Sheng Z, and Kelly DF* (2022) High-resolution imaging of human cancer proteins using microprocessor materials. ChemBioChem (17) e202200310.

Jonaid GM, Dearnaley WJ, Casasanta MA, Kaylor L, Dukes MJ, Spillman MS, and Kelly DF*(2022) Automated tools to advance high-resolution imaging in liquid. Microscopy & Microanalysis(20) 1-10. Cover figure

Pridham KJ, Shah F, Hutching KR, Sheng KL, Sujuan G, Liu M, Kanabur P, Lamouille S, Lewis G, Morales M, Jourdan J, Grek CL, Ghatnekar, GG, Varghese R, Kelly DF, Gourdie RG, Sheng Z (2022) Connexin 43 confers chemoresistance through activating PI3K. Oncogenesis (11) 2.

Jonaid GM, Dearnaley WJ, Casasanta MA, Kaylor L, Dukes MJ, Spillman MS, Kelly DF* (2021) High-resolution imaging of human viruses in liquid droplets. Advanced Materials (2103221). Cover figure

Casasanta MA, Jonaid GM, Kaylor L, Luqiu WY, Solares MJ, Schroen ML, Dearnaley WJ, Wilson J, Dukes MJ, Kelly DF* (2021) Microchip-based structure determination of low-molecular weight proteins using Cryo-Electron Microscopy. Nanoscale (13) 7285-7293.

Solares MJ, Jonaid GM, Luqiu WY, Liang Y, Evans MC, Dearnaley WJ, Sheng Z, Kelly DF*(2020) Isolation of disease-relevant p53 for Cryo-Electron Microscopy Analysis. Nature Protocol Exchange; doi: 10.21203/rs.3.pex-1294/v1.

Solares MJ, Jonaid GM, Luqiu WY, Liang Y, Evans MC, Dearnaley WJ, Sheng Z, Kelly DF*(2020) Microchip-based structure determination of disease-relevant p53. Analytical Chem. (92) 1558-15564. Cover figure

Dearnaley WJ, Schleupner B, Varano AC, Alden NA, Gonzalez F, Casasanta MA, Scharf BE, Dukes MJ, Kelly DF* (2019) Liquid-Cell Electron Tomography of Biological System. Nano Letters(19) 10, 6734-6741. Cover figure

Hauser M, Dearnaley WJ, Varano AC, Casasanta MA, McDonald SM, Kelly DF* (2019) Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles. Comp. Struct. Biotech. J. (17) 1178-1183.

Varano AC, Alden NA, Dearnaley WJ, Casasanta MA, Damiano J, McConnell J, Dukes M, and Kelly DF (2019) Customizable Cryo-EM Chips Improve 3D Analysis of Macromolecules. Microscopy and Microanalysis (25) S2:1310-1311.

Alden NA, Varano AC, Dearnaley WJ, Solares MJ, Luqiu WY, Liang Y, Sheng Z, McDonald SM, Damiano J, McConnell J, Dukes MJ, and Kelly DF* (2019) Cryo-EM-on-a-Chip: Custom-designed Substrates for the 3D Analysis of Macromolecules. Small (15):1900918. Cover figure

Liang Y, Dearnaley WJ, Alden NA, Solares MJ, Gilmore BL, Pridham KJ, Varano AC, Sheng Z, Alli E, Kelly DF* (2019) Correcting Errors in the BRCA1 Warning System. DNA Repair (73) 120-128.

Varghese RT, Young S, Pham L, Liang Y, Pridham KJ, Guo S, Murphy S, Kelly DF, Sheng Z (2018) Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival. Sci. Rep. 8(1):13621.

Gilmore BL, Varano AC, Dearnaley WJ, Liang Y, Marcinkowski BC, Dukes MJ, Kelly DF* (2018) Preparation of Tunable Microchips to Visualize Native Protein Complexes for Single-Particle Electron Microscopy. Protein Complex Assembly: Methods and Protocols. Chapter 3, 45-58.

Pridham KJ, Lamy L, Guo S, Varghese RT, Algino S, Liang Y, Farjadin R, Rodgers CM, Simonds GR, Kelly DF, Sheng Z (2018) PIK3CB/p110 is a Selective Survival Factor for Glioblastoma. Neuro Oncology 20(4) 27, 494-505.

Liang Y, Dearnaley W, Varano AC, Winton CE, Gilmore BL, Alden NA, Sheng Z, and Kelly DF* (2017) Structural Analysis of BRCA1 Reveals Modification Hot Spot. Science Advances. (3) e1701386.

Gilmore BL, Liang Y, Winton CE, Patel K, Karageorge V, Varano AC, Dearnaley W, Sheng Z, and Kelly DF* (2017) Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress. Sci. Rep. (7) 43435.

DiMemmo L, Varano AC, Haulenbeek J, Liang Y, Patel K, Dukes MJ, Zheng S, Hubert M, PiccoliS, and Kelly DF* (2017) Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy. Lab on a Chip (17) 315-322.

Winton CE, Gilmore BL, Tanner JR, Dukes MJ, Sheng Z, and Kelly DF* (2017) Tunable substrates improve imaging of viruses and cancer proteins. Microscopy Today 25(04) 22-27.

Varano AC, Harafuji N, Dearnaley W, Guay-Woodford L, Kelly DF* (2017) Preparation of Disease-related Protein Assemblies for Single Particle Electron Microscopy. Proteomics for Drug Discovery: Methods and Protocols 1647, 185-194.

Kanabur P, Guo S, Simonds G, Kelly DF, Gourdie R, Sheng Z (2016) Patient-derived glioblatoma stem cells respond differentially to targeted therapies. Oncotarget 7(52) 86406-86419.

Demmert AC, Dukes MJ, Pohlmann E, Patel K, Varano AC, Sheng Z, McDonald SM, Spillman M, Mirsaidov U, Matsudaira P, and Kelly DF* (2016) Visualizing Macromolecules in Liquid at the Nanoscale. (Chapter 17) Liquid Cell Electron Microscopy. Frances Ross (editor), Cambridge University Press.

Browning CL, Qin Q, Kelly DF, Prakash R, Vanoli F, Jasin M, Wise JP (2016) Prolonged Particulate Hexavalent Chromium Exposure Suppresses Homologous Recombination Repair in Human Lung Cells. Toxicological Sciences 153(1), 70-78.

Winton CE, Gilmore BL, Demmert AC, Karageorge V, Sheng Z, Kelly DF* (2016) A microchip platform for structural oncology applications. npj Breast Cancer 2, 16016.

Varghese RT, Liang Y, Guan T, Frank C, Kelly DF, Sheng Z (2016) Survival kinase genes present prognostic significance in glioblastoma. Oncotarget 7(15), 20140-20151.

Delatch DL, Dukes MJ, Varano AC, Kelly DF, Dukes AD (2015) Real-time imaging of lead nanoparticles in solution – determination of the growth mechanism. RSC Advances 5:104193.

Varano AC, Rahimi A, Dukes MJ, Poelzing S, McDonald SM, and Kelly DF* (2015) Visualizing Virus Particle Mobility in Liquid at the Nanoscale. Chem. Comm. (51), 16176-16179.

Gilmore BL, Winton CE, Demmert AC, Tanner, JR, Bowman S, Karageorge V, Patel K, Sheng Z, and Kelly DF* (2015) A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease. Sci. Rep. 5:14440.  

Rahimi A, Varano AC, Demmert AC, Melanson LA, McDonald SM, and Kelly DF* (2015) A Non-Symmetric Reconstruction Technique for Transcriptionally-Active Viral Assemblies. J. Anal. Mol. Tech. 2(1) 1-6.

Pohlmann ES, Patel K, Guo S, Dukes MJ, Sheng Z, and Kelly DF* (2015) Real-time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells. Nano Letters 15(4) 2329-2335.

Boudreaux CE, Kelly DF, McDonald SM. (2015) Electron microscopic analysis of rotavirus assembly-replication intermediates. Virology (477) 32-41.

Guo S, Liang Y, Murphy S, Huang A, Kelly DF, Sheng H, Sobrado P, and Sheng Z. (2015) A Rapid and High Content Assay That Quantitatively Measures Autophagy and Autophagy Flux with Potential Clinical Applications. Autophagy 11 (3) 560-572.

Dukes MJ, Thomas R, Damiano J, Klein KL, Balasubramaniam S, Kayandan S, Riffle JS, Davis RM, McDonald SM, and Kelly DF*. (2014) Improved Microchip Design and Application for In SituTEM of Macromolecules. Microscopy and Microanalysis (20), 338-345.

Balasubramaniam S, Kayandan S, Lin Y-N, Kelly DF, House MJ, Woodward RC, St. Pierre TG, Riffle JS, and Davis RM. (2014) Towards Design of Magnetic Nanoparticle Clusters Stabilized by Biocompatible Diblock Copolymers for T2-Weighted MRI Contrast. Langmuir 30(6) 1580-1587.

Kam JA, Demmert AC, Tanner, JR, McDonald SM, and Kelly DF*. (2014) Structural Dynamics of Viral Nanomachines. Technology 2(1) 1-5.

Pothayee N, Pothayee N, Hu N, Zhang R, Kelly DF, Koretsky, AP and Riffle JS. (2014) Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy. J. Materials Chemistry B (2) 1087-1099.

Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, and Wright ER. (2014) Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications. Microscopy and Microanalysis (20), 164-174.

Tanner JR, Demmert AC, Dukes MJ, Melanson LA, McDonald SM, and Kelly DF*. (2014) Cryo-SiN – An Alternative Substrate to Visualize Active Viral Assemblies. J. Anal. Mol. Tech. 1 (1), 1-6

Dukes MJ, Gilmore BL, Tanner JR, McDonald, SM and Kelly DF*. (2013) In Situ TEM of Biological Assemblies in Liquid. J. Vis. Exp. (82) doi:10.3791/50936.

Boudreaux CE, Vile D, Gilmore BL, Tanner JR, Kelly DF and McDonald SM. (2013) Rotavirus Core Shell Subdomains that Mediate Specific Polymerase Encapsidation into Virus Like Particles. J. Gen. Virol. 94 (8), 1818-1826.

Gilmore BL, Tanner JR, McKell AO, Boudreaux CE, Dukes MJ, McDonald SM and Kelly DF*. (2013) Molecular Surveillance of Viral Processes using Silicon Nitride Membranes.Micromachines, 4 (1), 90-102.

Dukes MJ, Jacobs BW, Morgan DG, Hegde H and Kelly DF*. (2013) Visualizing Nanoparticle Mobility in Liquid at Atomic Resolution. Chem. Comm. (49), 3007-3009.

Gilmore BL, Showalter SP, Dukes MJ, Tanner JR, Demmert AC, McDonald SM, and Kelly DF*.(2013) Visualizing viral assemblies in a nanoscale biosphere. Lab Chip, 13 (2), 216-219.

Sharma G, Pallesen J, Das S, Grassucci R, Langlois R, Hampton C, Kelly DF, Des Georges A, and Frank J. (2013) Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome. J. Struct. Biol., 181(2), 190-194.

Tanner JR, Degen K and Kelly, DF*. (2012) Capturing RNA-dependent pathways for cryo-EM analysis. Comp. Struc. Biotech. J., (1) 1: e2012040003.

Degen K, Dukes MJ, Tanner JR and Kelly DF*. (2012) The development of Affinity Capture Devices – a nanoscale purification platform for biological In-Situ Transmission Electron Microscopy. RSC Adv., 2: 2408-2412.

Chiu Po-Lin, Kelly DF and Walz T. (2011) The use of trehalose in the preparation of specimens for molecular electron microscopy. Micron, 42: 763-772.

Norville JE, Kelly DF, Knight TF, Belcher AM and Walz T. (2011). Fast and easy protocol for thepurification of recombinant S-layer protein for synthetic biology applications. Biotech. J., 6: 807-811.

Kelly DF, Dukovski D and Walz T. (2010) Strategy for the Use of Affinity Grids to Prepare Non-His-Tagged Macromolecular Complexes for Single-Particle Electron Microscopy. J. Mol. Biol., 400 (4),675-681. (Cover figure)

Kelly DF, Dukovski D and Walz T. (2010) A Practical Guide to the Use of Monolayer Purification and Affinity Grids. Methods in Enzymology, (Chapter 4) 481: 83-107.

Kelly DF, Lake RJ, Middlekoop TC, Fan H-Y, Artavanis-Tsakonas S and Walz T. (2010) Molecular Structure and Dimeric Organization of the Notch Extracellular Domain as Revealed by Electron Microscopy. PLoS ONE, 5 (5): e10532.

Dukovski D, Li Z, Kelly DF, Mack E and Walz T. (2009) Structural and functional studies on the stalk of the transferrin receptor. Biochim. Biophys. Res. Commun., 381: 712-719.

Kelly DF, Abeyrathne PD, Dukovski D and Walz T (2008) The Affiinity-Grid: a pre-fabricated EM grid for monolayer purification. J. Mol. Biol., 382 (2): 423-433. (Cover figure)

Kelly DF, Dukovski D and Walz T. (2008) Monolayer purification: a rapid method for isolating protein complexes for single-particle Electron Microscopy. Proc. Natl. Acad. Sci. U.S.A., 105: 4703-4708. (Cited by Faculty of 1000 – Biology)

Norville JE, Kelly DF, Knight TF, Belcher AM and Walz T. (2007) 7Å projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals.  J. Struct. Biol., 160 (3): 313-323.

Taylor DW, Kelly DF, Chen A and Taylor KA. (2007) On the Freezing and Identification of Lipid Monolayer Crystals for Cryo-Electron Microscopy. J. Struct. Biol., 160 (3): 305-312.

Kelly DF, Lake RJ, Walz T and Artavanis-Tsakonas, S. (2007) Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless. Proc. Natl. Acad. Sci. U. S. A., 104: 9591-9596.

Kelly DF, Taylor DW, Bakolista C, Bobkov A, Bankston L, Liddington RC and Taylor KA. (2006) A 3D Reconstruction of the alpha-Actinin-Vinculin head domain complex determined by Cryo-Electron Microscopy. J. Mol. Biol., 357 (2): 562-573.

Kelly DF and Taylor KA. (2005) Identification of the beta-1 Integrin Binding site on alpha-Actinin by Cryo-Electron Microscopy.  J. Struct. Biol., 149 (3): 290-302. *(Cover figure)

Morris RC, Brooks BJ, Eriotou P, Kelly DF, Sagar S, Hart KL and Elliott MS (1995) Activation of transfer RNA-guanine ribosyltransferase by protein kinase C.  Nucleic Acids Res., 23 (13): 2492-2498.